The campaign features nonlinear gameplay and has multiple endings. Both time periods involve the characters pursuing Raul Menendez, a Nicaraguan cartel leader, who is responsible for kidnapping Woods in the 80s and later sparking a second Cold War in 2025.

In the 1980s, the player switches control between Alex Mason and Frank Woods, two of the protagonists from Black Ops, while in 2025, the player assumes control of Mason's son, David ( codenamed 'Section'). The game's campaign follows up the story of Black Ops and is set in the late 1980s and 2025. A corresponding game for the PlayStation Vita, Call of Duty: Black Ops: Declassified, was developed by nStigate Games and also released on November 13.

Black Ops II is the ninth game in the Call of Duty franchise of video games, a sequel to the 2010 game Call of Duty: Black Ops and the first Call of Duty game for the Wii U. It was released for Microsoft Windows, PlayStation 3, and Xbox 360 on November 12, 2012, and for the Wii U on November 18 in North America and November 30 in PAL regions. Call of Duty: Black Ops II is a 2012 first-person shooter video game developed by Treyarch and published by Activision.

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